Use that is common
Atorvastatin is a cholesterol-lowering which used used to lower the risk of stroke, heart attack or other heart complications in patients with coronary heart disease or second kind of diabetes or to deal with high cholesterol. Atorvastatin helps to clear harmful low-density lipoprotein cholesterol from the blood and by limiting the capability to form new LDL cholesterol of the body's. Hence can help prevent hardening of the arteries as well as heart disease, conditions which will result in vascular disease, stroke, heart attack.
Take it orally with or without any food. Atorvastatine ought to be taken with full glass of water.
The typically dose for adults is 10 milligrams once daily.
The commonly dose for children 10 to 17 years old is 10 mg once daily.
Using Atorvastatin in kids less than ten years old isn't recommended and dose must be determined by your family doctor.
Note: this instruction presented here only for review. Before using, it is quite necessary to talk to your physician. It help you to get best results.
Precautions
People who have kidney disease, underactive thyroid glands, diabetes, or muscle disorder occasionally want additional tests before or during atorvastatin therapy since dosage adjustments may be deemed necessary. Don't use considerable amounts of alcohol while taking this drug because it could worsen the adverse effects of this medication on the liver. Atorvastatin really should not be utilized during pregnancy, lactating without physician's advice or becoming pregnant. Do not use Atorvastatin before breastfeeding without doctor's permission.
Contraindications
Atorvastatin is not permitted to those who have liver problems or abnormal liver function tests that were unexplained. Don't put it to use if you are taking an HIV protease inhibitor (eg, ritonavir), itraconazole, or mibefradil. Additionally Atorvastatin contraindicated if you're hypersensitive to any components of this medicine, pregnancy or breast-feeding.
Side effect that is potential
They may contain all kinds of an allergic reaction. Also the most possible negative effects include:
muscle pain, tenderness, or weakness with fever or flu symptoms; or
Less serious contain:
Gas, constipation, bloating;
stuffy nose;
Itching, skin rash;
headache.
If you experience one of them tell your doctor when possible and cease using Atorvastatin. Additionally consult with your doctor about any side effect that seems strange.
Drug interaction
Atrovastatin interact together with these drugs: digoxin; erythromycin or clarithromycin; gemfibrozil or fenofibrate; niacin; an antifungal medication like itraconazole, fluconazole, or ketoconazole; drugs that weaken your immune system like cancer medicine or steroids, cyclosporine, sirolimus, tacrolimus, and others; HIV or AIDS drug such as indinavir, nelfinavir, ritonavir, lopinavir-ritonavir, or saquinavir. Also note that interaction between two medications does not necessarily mean you have to stop taking one. As usual it impacts the the effect of drugs, so check with your doctor about how it interactions are being managed or should be handled.
Missed dose
Please take action as soon as you remember, if you forgot to take your dose in time. However tend not to take if it is too late or almost time for your next dose. Do not increase your dose that is recommended. Take your generally dose next day in the same regularly time.
Overdose
Symptoms of Atorvastatin is not understood nicely but most potential comprise a serious drop in a faster heartbeat and also blood pressure. Should you experience one of them or any unusual symptoms call your doctor promptly.
Storage
Do not use after expiration duration.
Disclaimer
We supply just general information about medications that doesn't cover all directions, potential drug integrations, or precautions. Any specific directions for a particular patient should be agreed with physician or your health care advisor in charge of the case. We disclaim reliability of this advice and blunders it could feature. We are not liable for any direct, indirect, special or other indirect damage as an effect of any use of the information with this web site and also for effects of self-treatment.
I m on a 30 day trial offer from Crestor 20mg to replace my Simvastatin 20mg. I m sure I know the answer to this question but hearing other opinions would be welcomed As I understand it, Crestor is a bit stronger than Simvastatn, or should I say, You can take a smaller dose of Crestor to equal Simvatstatin. Other than the equivalent dose change is there any other differences - side effects I should be looking for.
I wish you luck with 20mg my friend and really hope you dont suffer any liver damage. Crestor is the most powerful statin to date, much stronger than Lipitor which is very strong. The starting dosage recommended for severe artery disease with crestor is 10mg, which lowers c-ldl by a whopping 46-52. This is a lot, and most people don t need this much of a reduction, certainly that much of the powerful drug. You can get 5mg, but this is the lowest. It has been shown that 2.5mg lowers c-ldl by 40 and 1mg by 34. Crestor studies showed that 1mg reduced c-ldl by the same level as 20-40mg of simvastatin. As the American Journal of cardiology stated, as levels of statins double, so does the frequency of liver damage. It also states why take more than your body needs.
So, please be careful, I would hate to see you become seriously ill my friend. 20mg of crestor probably has the same strength as 400mg of simvastatin.
Just to add, around 1 in 2000-5000 people on statins get nerve damage, but this number is too small to concern the drug companies. However, as millions and millions more people start to take statins, we will see an increase in this frequency. This also came from a statement in the American journal of cardiology.
Actually, two recent studies done in Greece and China have confirmed that statin therapy has been shown to not have effects on the liver as once though, in fact those with abnormal liver function prior to statin treatment showed improvement in their liver function.
-- Long-term use of cholesterol-lowering statins does not increase the risk of liver disease in patients with abnormal liver function, and can actually improve liver function, according to a new study that challenges widespread belief.
The researchers also pointed out that this study is the first to show that statins provide a substantially greater cardiovascular benefit in patients with abnormal liver function than in those with normal liver function.
The study, published in the Nov. 24 online edition of The Lancet, included 437 patients with moderately abnormal liver tests believed to have non-alcoholic fatty liver disease. Statins were given to 227 patients, while the other 210 the control group received no treatment.
After three years of follow-up, the patients taking statins did not have a higher rate of liver problems than those in the control group. In addition, levels of alanine aminotransferase ALT -- a biomarker of liver problems -- decreased or normalized in the patients taking statins but worsened in the control group.
The investigators also found that patients with abnormal liver tests who took statins had a 39 to 68 reduced risk of cardiovascular events such as heart attack and stroke.
In fact, the folks doing the study have recommended that the mention of side effects on the liver be removed from the patient information leaflet.Overall, the risk of side effects from statins are 1 in 2,200 making statins one of the safest drugs available. Also, the risk of side effects to the nervous system is. 025 of those on statins which compared to. 021 in the placebo control group based on the Jupiter study. The overall incidence of side effects was 1 in 2221 in the statin group compared to 1 in 2223 in the placebo group.
Also, they are now prescribing statins before and after invasive surgical procedures as a result of their anti-inflammatory properties which is why they are also being used now to treat pneumonia.
Larry, Crestor is more powerful that Simvastatin, however the dangerous side effects are really only a factor once your dosage exceeds 80mg.
Anyways, good luck with your decision,
Apparently the Americans and the Greeks disagree then.
Quote A new study published in the Journal of the American College of Cardiology examined the results of 23 large clinical trials of statins for patterns of liver damage, measured by an increased concentration of the enzymes released when liver cells die.
Quote The researchers found that high-dose statins caused 2.4 times as many cases of liver damage as low-dose statins, or 271 cases per 100,000 patients. When the researchers looked at individual statin drugs, they found that Zocor simvastatin was 1.6 more dangerous in high doses than low doses, and Lipitor atorvastatin was 4.0 times more dangerous.
Quote The new study is consistent with prior studies, such as one in the New England Journal of Medicine that found a 5.5 higher risk of liver damage from maximum-dose Lipitor relative to a lower dose. Another New England Journal of Medicine study found that maximum-dose Lipitor was 4.5 times more likely to cause liver damage than a placebo.
another Quote The study in the Journal of the American College of Cardiology also found that rates of cancer among those using statins went up as both LDL and total cholesterol levels decreased. Likewise, cancer risk increased along with the dose of statins being taken.
Now China is claiming that THEIR research has found no difference with cancer rates. What would you suggest we do to stop the confusion with conflicting research. Ignore the US research. ignore other nations research. how the heck are you supposed to believe. You say the Greeks and Chinese at the moment, but China is the new financial centre of the world and very influential, so it s convenient for drug companies to use them. I m beginning to wonder if you can trust anything that comes out of a lab, obviously someone isn t able to use the equipment, so who is it. lol
I can go point to point, quote to quote and link to link with you on this subject, but I won t as I respect your opinion.
Having said that, I spend many hours each week doing volunteer work where I am privileged to associate with some great cardiologists.. They share the latest studies and data with me and I spend hours on other cholesterol related forums on the Internet. Consider this statement supporting the Jupiter study from a recent publication;
And this trial did not tell us the risks of lifelong, or even very long-term, Crestor therapy.
But what it did tell us, with a very high degree of statistical surety, was this: Giving Crestor to patients similar to the ones enrolled in this study can be expected to result in significantly and substantially improved cardiovascular outcomes, and in a relatively short period of time.
There are a lot of reasons that a lot of people are unhappy about these results. Chief among these are that Crestor is very expensive, and if the results of this study were taken to its logical extreme, we would be spending billions of dollars each year on Crestor.
The articles appearing this week in the Archives vary in quality from quite reasonable criticisms to absurdly polemical.
The main article largely consisted of a string of ad hominem attacks aimed at the presumed biases of the sponsor, the clinical investigators, and even the chair of the DSMB a highly respected individual known for his rigid objectivity. While it may be legitimate to criticise the bias built-in to the study design for instance, only the sponsor s statin was used in this trial, it remains true that, given that the JUPITER design is what it is, the resultant data - which can only be considered striking - must be evaluated on its own merits. Ironically, the chief author of this critical paper is himself a member of a fringe medical group known as The International Network of Cholesterol Skeptics THINCS, whose stated mission is to oppose the notion that high cholesterol and animal fat play a role in cardiovascular disease. Members of THINCS also take an extraordinarily strong position opposing statins for any clinical use whatsoever. The irony, of course, is that this striking bias was not disclosed in an article whose main thrust was to criticise the disclosed biases of the JUPITER investigators.
Many complain about bias, but don t represent their own. FYI, the study in Greece was not funded in any way by any drug company. I do agree with you, what to believe. I will go with my personal experience and what can be proven. As soon as some one proves corruption in the studies, it will all just be conjecture to me.
but that s another point, you say go with what is proven. Which is proven and which is truth. when several studies conclude different things, how do you possibly know which is proven. they can t all be correct.
If you designed an electric car and gave 10 to each of 2 research companies to test them and publish the results. One said all 10 cars broke down and were a waste of money, the other said they were fantastic, which would the public believe, or be expected to believe. Its the same with many drugs, so no wonder the public are asking questions and becoming concerned.
I would start off at 2.5mg every other day. Check your numbers then titrate up accordingly.
Crestor is so powerful that you don t need a lot which lowers the risk of side effects.
I bet you wished you hadn t asked now lol. Are you more confused than you were before asking.
LOL.. Same thing happened with one or two other threads of mine. I don t mind at all and as a mater of fact, both of you have given quite a bit of information in more ways than one.
You both confirm my observation that Crestor is, for lack of a better description, more powerful than Simvastatin, I believe 2/3 to2x. . Both the PCP and Cardiologist want me to go back to my original 40mg Simvastatin and since Crestor has a one month trial offer for people in similar financial situations as I m in, we re going to try that at 20mg. So, In essence, we re good to go as to the dose, it s just a matter of side effects which with research suggests most effects are similar to Simvastatin.
Q: but that s another point, you say go with what is proven. Which is proven and which is truth.
.Isn t something that is proven a fact and a fact is the truth. I don t want to fog the issue. :
My cardiologist changed me over from 40MG of Simvastatin to the same dosage of Crestor and I have been taking it for about a year now. So far, no problems and my LDL level has gone down even further since taking the Crestor.
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I ask because the Lipitor fullpage ads in national magazines say DO NOT BREAK TABLETS and they Lipitor website from Pfizer also says on the meds page DO NOT.
Apparently the Americans and the Greeks disagree then. Quote A new study published in the Journal of the American College of Cardiology examined the results of 23.
Sole of generic lipitor 125 mcg/ml renal impairment is HIRING take LEVAQUIN, exactly as antioxidants 0 i kept with certain patients aged 15 to ticagrelor or clot.
Atorvastatin, marketed under the trade name Lipitor among others, is a member of the drug class known as statins, which are used primarily as a lipid-lowering agent.
Statins have been almost universally hailed as wonder drugs by medical authorities around the world. The market for statins was 26 billion in 2005, and sales for.
Oct 07, 2005 Is Lovastatin just as effective at lowering LDL as Lipitor is. I do the diet and exercise every single day. I currently take 10 mgs. of lipitor and it has.
Common Questions and Answers about Lipitor weight loss side effects.